Lipotoxicity and Decreased Islet Graft Survival

Lipotoxicity and Decreased Islet Graft Survival

OBJECTIVE To evaluate if baseline serum lipids are associated with islet graft survival in type 1 diabetes islet transplant (ITx) recipients. RESEARCH DESIGN AND METHODS Baseline fasting lipid profile was collected from 44 ITx recipients. Comparisons were performed between subjects below and above the median values of each lipid fraction. Differences in outcomes were compared by Kaplan-Meier cu...

Primary Graft Function, Metabolic Control, and Graft Survival After Islet Transplantation

OBJECTIVE To investigate the influence of primary graft function (PGF) on graft survival and metabolic control after islet transplantation with the Edmonton protocol. RESEARCH DESIGN AND METHODS A total of 14 consecutive patients with brittle type 1 diabetes were enrolled in this phase 2 study and received median 12,479 islet equivalents per kilogram of body weight (interquartile range 11,072-1...

Pancreatic Islet Transplantation Modifications of Islet Properties to Improve Graft Survival

Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts.

Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity

Chronic intake of saturated free fatty acids is associated with diabetes and may contribute to the impairment of functional beta cell mass. Mitogen activated protein kinase 8 interacting protein 1 also called islet brain 1 (IB1) is a candidate gene for diabetes that is required for beta cell survival and glucose-induced insulin secretion (GSIS). In this study we investigated whether IB1 express...